2027Buz Devri 6: Kaynama Noktası— Sid (voice)
2027The Exorcist: Martyrs
2027Untitled Daniels Event Film
2025Bob Trevino Likes It— Bob Trevino
2025Kurşun Asker— Luke
2025This Ordinary Thing— Self (voice)
2025A Grammy Celebration of Latin Music— Self
2022Vahşi Gece— Scrooge
2022John Leguizamo Live at Rikers
2022Hayatta Kalan— Bill "Pepe" Miller
2022Menü— Movie Star
2021Enkanto: Sihirli Dünya— Bruno Madrigal (voice)
2021Waiting for Godot— Estragon
2021Dark Blood— Misael
2020Gece Nöbeti— Detective Espada
2020Eleştirel Düşünce— Mario Martinez
2019Güneş de Bir Yıldızdır— Jeremy Martinez
2019Ateşle Oyun— Rodrigo
2019It Takes a Lunatic— Self
2019Raúl Juliá: The World’s a Stage— Self
2018John Leguizamo's Latin History for Morons— Self
2017Jekyll Island— George Diebold
201711:55— Berto
2016Leş Sınırı— Atticus
2016Stealing Cars— Montgomery De La Cruz
2016Casus— Emir Abreu
2016Buz Devri: Büyük Yumurta Macerası— Sid (voice)
2016Porzingod
2016Perros— Misael
2016Michael Jackson's Journey from Motown to Off the Wall— Self
2016Scrat: Spaced Out— Sid (voice) (uncredited)
2015John Wick: Calling in the Cavalry— Self
2015American Ultra— Rose
2015Kız Kardeşler— Dave
2015Deneyci— Taylor
2015Meadowland— Pete
2015Cosmic Scrat-tastrophe— Sid (voice)
2015The Latin Explosion: A New America— Self - Narrator
2015Fındık Hırsızları— Fly Boy / Liam (voice)
2015Ice Age: No Time for Nuts 4-D— Sid (voice)
2015John Wick: NYC Noir— Self
2014Zor Biraderler— Santiago
2014Anarşi— Pisanio
2014John Leguizamo: Ghetto Klown— Self
2014Fugly!— Jesse
2014Super Mario Bros: This Ain't No Video Game— Self - Luigi Mario
2013Göster Gününü 2— Javier
2013Dinozorlarla Yürümek— Alex (voice)
2013Balık ile Karaker'in Maceraları— Chips (voice)
2013Danışman— Coverall Man Randy
2013Tales From a Ghetto Klown— Self
2012Aşk ve Para— Jimmy Alpha
2012El paseo 2— Lucho
2011Buz Devri: Yeni Yıl Macerası— Sid (voice)
2011Pelotero— Narrator (voice)
2011The Latino List— Self
2011Scrat's Continental Crack-Up: Part 2— Sid (voice)
2010Kıyamet Gecesi— Paul
2010Repo Men— Asbury
2009Rage— Jed
2009The Ministers— Dante Mendoza
2009Oyuncu— Freek
2008Surviving Sid— Sid (voice)
2008Mistik Olay— Julian
2008St. Anna Mucizesi— Enrico
2008Bebek Bakıcıları— Michael Beltran
2008Orijinal Cinayet(ler)— Det. Simon Perez
2008Bedel— Felix De La Pena
2008Cennet Yolculuğu— Roger Pena
2008Visions of 'The Happening'— Self
2008The Happening: Elements of a Scene— Self
2007Kolera Günlerinde Aşk— Lorenzo Daza
2007Where God Left His Shoes— Frank Diaz
2007ShowBusiness: The Road to Broadway— Self
2006Buz Devri 2: Erime Başlıyor— Sid (voice)
2006Kaçamak— Hannibal
2006Müstakbel Damat— TC (Tony)
2005Ölüler Ülkesi— Cholo
2005Baskın— Beck
2005Hayal— Antonio
2004Crónicas— Manolo Bonilla
2004Dora the Explorer: Super Silly Fiesta!— Silly Mail Bird (voice)
2003Bulanık— Spider Mike
2003Yenilmez— Lex Vargas
2002Suç Batağı— Victor Rosa
2002John Leguizamo: Sexaholix... A Love Story— Self
2002Zig Zag— Dean Singer
2002Point of Origin— Keith Lang
2002AFI's 100 Years... 100 Passions: America's Greatest Love Stories— Self
2002What’s the Worst That Could Happen: Scene Stealers— Self
2002Dora the Explorer: Pirate Adventure— Pirate Pig Captain (voice)
2001Daha Kötüsü Olamaz— Berger
2001The Night Club of Your Dreams: The Making of 'Moulin Rouge'— Self
2001De Superman à Spider-Man: L'aventure des super-héros— Clown / Violator (archive footage)
2001Dr. Dolittle 2— Rat #2 (voice, uncredited)
2000Dünya'dan Sonra— Gune (voice)
2000King of the Jungle— Seymour
1999Summer of Sam— Vinny
1999Joe the King— Jorge
1998Suç Kapanı— Chino
1998John Leguizamo: Freak— Self
1998Frogs for Snakes— Zip
1998Kids Are Punny— Self / Self - Voice
1998Dr. Dolittle— Rat #2 (Voice)
1997Spawn— Clown / Violator
1997The Pest— Pest
1997A Brother's Kiss— Lefty
1997The Making of 'Spawn'— Self
1996Kritik Karar— Rat
1996Fanatik— Manny
1995A Pyromaniac's Love Story— Sergio
1995Wong Foo'ya Teşekkürler!— Chi-Chi Rodriguez
1993Night Owl— Angel
1993Carlito'nun Yolu— Benny Blanco
1993Süper Mario Kardeşler— Luigi Mario
1993John Leguizamo: Spic-O-Rama
1992The Puerto Rican Mambo (Not a Musical)— 'Paco' in Puerto Rico/'Guess My Nationality' Party Guest
1992Whispers in the Dark— John Castillo
1992Time Expired— Ruby
1991Hangin' with the Homeboys— Johnny
1991Mambo Mouth
1991İntikam Yemini— Boy in Alley
1991That Burning Question
1991Poison— Chancho ("Homo")
1991Regarding Henry— Liquor Store Gunman
1991NYPD Mounted
1990İntikam— Ignacio
1990Street Hunter— Angel
1990Gentille Alouette— Ortiz
1990Madonna: The Immaculate Collection— Friend of Boyfriend (segment "Borderline")
1989Savaş Günahları— Private Antonio Diaz
1985Cocaïne— Macetero
—The Nickelodeon Mega Music Fest— Self
—All Day & All Night
—Bullet Catch— George
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